检索范围:
排序: 展示方式:
Overlap maximum matching ratio (OMMR): a new measure to evaluate overlaps of essential modules
Xiao-xia ZHANG,Qiang-hua XIAO,Bin LI,Sai HU,Hui-jun XIONG,Bi-hai ZHAO
《信息与电子工程前沿(英文)》 2015年 第16卷 第4期 页码 293-300 doi: 10.1631/FITEE.1400282
关键词: Protein-protein interaction network Essential protein modules Overlap Overlap maximum matching ratio
《医学前沿(英文)》 2022年 第16卷 第3期 页码 403-415 doi: 10.1007/s11684-021-0858-1
关键词: myeloproliferative neoplasms IRF4 IRF8 hydroxyurea essential thrombocythemia
Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis
null
《医学前沿(英文)》 2016年 第10卷 第2期 页码 183-190 doi: 10.1007/s11684-016-0440-4
We performed weighted gene coexpression network analysis (WGCNA) to gain insights into the molecular aspects of hepatocellular carcinoma (HCC). Raw microarray datasets (including 488 samples) were downloaded from the Gene Expression Omnibus (GEO) website. Data were normalized using the RMA algorithm. We utilized the WGCNA to identify the coexpressed genes (modules) after non-specific filtering. Correlation and survival analyses were conducted using the modules, and gene ontology (GO) enrichment was applied to explore the possible mechanisms. Eight distinct modules were identified by the WGCNA. Pink and red modules were associated with liver function, whereas turquoise and black modules were inversely correlated with tumor staging. Poor outcomes were found in the low expression group in the turquoise module and in the high expression group in the red module. In addition, GO enrichment analysis suggested that inflammation, immune, virus-related, and interferon-mediated pathways were enriched in the turquoise module. Several potential biomarkers, such as cyclin-dependent kinase 1 (CDK1), topoisomerase 2α (TOP2A), and serpin peptidase inhibitor clade C (antithrombin) member 1 (SERPINC1), were also identified. In conclusion, gene signatures identified from the genome-based assays could contribute to HCC stratification. WGCNA was able to identify significant groups of genes associated with cancer prognosis.
关键词: hepatocellular carcinoma coexpression module microarray prognosis
Shasha ZENG, Weiping PENG, Tiaoyu LEI
《机械工程前沿(英文)》 2020年 第15卷 第1期 页码 12-23 doi: 10.1007/s11465-019-0555-9
关键词: distributed parameterized intelligent product platform generalized module isomorphism analysis product family
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 437-443 doi: 10.1007/s11684-016-0472-9
A phase II study (A2202) was performed to evaluate the efficacy and safety of JAK inhibitor ruxolitinib in 63 Chinese MF patients. Ruxolitinib was given twice a day (bid) at a starting dose of 15 mg (n=25) or 20 mg (n=38) based on a baseline platelet count. About 94.7% of the patients achieved a reduction in spleen size, 27.0% of which exhibited significant reduction (≥35%) at week 24. Significant improvement in debilitating constitutional symptoms, as assessed by MFSAF v2.0, was observed in patients treated with ruxolitinib. Ruxolitinib treatment was generally well tolerated by Chinese patients. Although the treatment was associated with an increase in certain adverse events (AEs) that were established as identified risks (anemia and thrombocytopenia), these AEs were considered manageable in this clinical setting. Ruxolitinib provided substantial reductions in splenomegaly and improvements in symptoms, and was well-tolerated by Chinese patients with MF.
LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping
《医学前沿(英文)》 2008年 第2卷 第3期 页码 309-313 doi: 10.1007/s11684-008-0059-1
关键词: specific amplification essential thrombocythemia Single-tube bi-directional JAK2V617F-positive JAK2V617F detection
赵宪文
《中国工程科学》 2000年 第2卷 第5期 页码 66-71
从森林火灾成灾的三个基本因子(火源、环境和可燃物)入手,在宏观上对西南地区森林火灾预报方法进行了探讨。在预测林火发生方面,考虑到人为火是发生森林火灾的主要原因,有很大随机性,因而采用了马尔科夫随机过程理论。在分析成灾环境时,采用了与天、地、生相关分析的方法。特别在可燃物的贮量估测方面,用航天遥感数据,提出一套新的框算方法,为在区域的尺度上估测森林火灾给出了有效的、定量的方法,从而提高了可信度。
Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group
JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong
《医学前沿(英文)》 2007年 第1卷 第2期 页码 230-233 doi: 10.1007/s11684-007-0045-z
关键词: case-control significant difference reaction-restriction fragment C825T polymorphism evidence
Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction
Hong LI,Ziding ZHANG
《农业科学与工程前沿(英文)》 2016年 第3卷 第2期 页码 102-112 doi: 10.15302/J-FASE-2016100
关键词: plant–pathogen interactions systems biology omics plant immunity protein–protein interaction network
null
《医学前沿(英文)》 2014年 第8卷 第2期 页码 227-235 doi: 10.1007/s11684-014-0327-1
Accelerated senescence is important because this process is involved in tumor suppression and has been induced by many chemotherapeutic agents. The platinum-based chemotherapeutic agent cisplatin displays a wide range of antitumor activities. However, the molecular mechanism of cisplatin-induced accelerated senescence in hepatocellular carcinoma (HCC) remains unclear. In the present study, the growth inhibitory effect of cisplatin on HepG2 and SMMC-7721 cells was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cellular senescence was then assessed by β-galactosidase assay. Senescence-related factors, including p53, p21, and p16, were evaluated by quantitative reverse transcription-polymerase chain reaction. Reactive oxygen species (ROS) was analyzed by flow cytometry. Our results revealed that cisplatin reduced the proliferation of HepG2 and SMMC-7721 cells in a dose- and time-dependent manner. Senescent phenotype observed in cisplatin-treated hepatoma cells was dependent on p53 and p21 activation but not on p16 activation. Furthermore, cisplatin-induced accelerated senescence depended on intracellular ROS generation. The ROS scavenger N-acetyl-L-cysteine also significantly suppressed the cisplatin-induced senescence of HepG2 and SMMC-7721 cells. In conclusion, our results revealed a functional link between intracellular ROS generation and cisplatin-induced accelerated senescence, and this link may be used as a potential target of HCC.
关键词: reactive oxygen species senescence cisplatin hepatocellular carcinoma
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 70-76 doi: 10.1007/s11684-011-0119-9
Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC ? in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC ? functions in vivo, and PKC ? has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC ? on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC ? could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC ? signal pathway in the developing brain.
关键词: protein kinase C ? signal transduction neurogenic disease
Wheat gluten protein and its impacts on wheat processing quality
Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM
《农业科学与工程前沿(英文)》 2019年 第6卷 第3期 页码 279-287 doi: 10.15302/J-FASE-2019267
Before the advent of the wheat genomic era, a wide range of studies were conducted to understand the chemistry and functions of the wheat storage proteins, which are the major determinants of wheat flour the suitability of wheat flour for various end products, such as bread, noodles and cakes. Wheat grain protein is divided into gluten and non-gluten fractions and the wheat processing quality mainly depends on the gluten fractions. Gluten provides the unique extensibility and elasticity of dough that are essential for various wheat end products. Disulfide bonds are formed between cysteine residues, which is the chemical bases for the physical properties of dough. Based on the SDS-extractability, grain protein is divided into SDS-unextractable polymeric protein (UPP) and SDS-extractable polymeric protein. The percentage of UPP is positively related to the formation of disulfide bonds in the dough matrix. In the wheat genomic era, new glutenins with long repetitive central domains that contain a high number of consensus hexapeptide and nonapeptide motifs as well as high content of cysteine and glutamine residues should be targeted.
关键词: wheat gluten consensus motifs disulfide bonds SDS-unextractable polymeric protein glutenins gliadins processing quality storage protein
《化学科学与工程前沿(英文)》 2023年 第17卷 第8期 页码 1131-1139 doi: 10.1007/s11705-023-2321-0
关键词: biomass riboflavin sodium phosphate silk protein multifunctional modification flame retardant
Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:
null
《医学前沿(英文)》 2018年 第12卷 第3期 页码 319-323 doi: 10.1007/s11684-017-0553-4
Antithrombin and protein C are two crucial members in the anticoagulant system and play important roles in hemostasis. Mutations in and lead to deficiency or dysfunction of the two proteins, which could result in venous thromboembolism (VTE). Here, we report a Chinese 22-year-old young man who developed recurrent and serious VTE in cerebral veins, visceral veins, and deep veins of the lower extremity. Laboratory tests and direct sequencing of and were conducted for the patient and his family members. Coagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreased protein C activity resulting from a small insertion mutation c.848_849insGATGT in and a short deletion variant c.572_574delAGA in . This combination of the two mutations was absent in 400 healthy subjects each from southern and northern China. Then, we summarized all the mutations of the and gene reported in the Chinese Han population. This study demonstrates that the combination of antithrombin deficiency and decreased protein C activity can result in severe VTE and that the coexistence of different genetic factors may increase the risk of VTE.
关键词: antithrombin deficiency protein C activity mutation variant venous thromboembolism anticoagulants
标题 作者 时间 类型 操作
Overlap maximum matching ratio (OMMR): a new measure to evaluate overlaps of essential modules
Xiao-xia ZHANG,Qiang-hua XIAO,Bin LI,Sai HU,Hui-jun XIONG,Bi-hai ZHAO
期刊论文
expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential
期刊论文
Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis
null
期刊论文
Isomorphism analysis on generalized modules oriented to the distributed parameterized intelligent product
Shasha ZENG, Weiping PENG, Tiaoyu LEI
期刊论文
Efficacy and safety of JAK inhibitor INC424 in patients with primary and post-polycythemia vera or post-essential
null
期刊论文
Observation of a higher JAK2 V617F homozygous mutated clone in polycythemia vera compared to essential
LIU Hongxing, TONG Chunrong, CAI Peng, GU Jiangying, LIN Yuehui, TENG Wen, WANG He, ZHANG Ying, ZHU Ping
期刊论文
Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group
JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong
期刊论文
Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction
Hong LI,Ziding ZHANG
期刊论文
Reactive oxygen species generation is essential for cisplatin-induced accelerated senescence in hepatocellular
null
期刊论文
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
null
期刊论文
Wheat gluten protein and its impacts on wheat processing quality
Wujun MA, Zitong YU, Maoyun SHE, Yun ZHAO, Shahidul ISLAM
期刊论文
Construction of sustainable, colored and multifunctional protein silk fabric using biomass riboflavin
期刊论文